What is the 3-(4'-Bromo[1,1'-biphenyl]-4-yl)-1,2,3,4-tetrahydro-1-naphthalenol?

3-(4'-Bromo[1,1'-biphenyl]-4-yl)-1,2,3,4-tetrahydro-1-naphthalenol is Cream To Pale Solid Powder., while it's Molecular Formula is C22H19BrO. Cream To Pale Solid Powder. 3-(4''-Bromo[1,1''-biphenyl]-4-yl)-1,2,3,4-tetrahydro-1-naphthalenol is used to prepare 4-hydroxycoumarin derivatives with antitumor activities. It is also used to synthesize diphenacoum and brodifacoum (B677900) as the rodenticides.

What is the 3-(4'-Bromo[1,1'-biphenyl]-4-yl)-1,2,3,4-tetrahydro-1-naphthalenol?

3-(4'-Bromo[1,1'-biphenyl]-4-yl)-1,2,3,4-tetrahydro-1-naphthalenol is Cream To Pale Solid Powder., while it's Molecular Formula is C22H19BrO. Cream To Pale Solid Powder. 3-(4''-Bromo[1,1''-biphenyl]-4-yl)-1,2,3,4-tetrahydro-1-naphthalenol is used to prepare 4-hydroxycoumarin derivatives with antitumor activities. It is also used to synthesize diphenacoum and brodifacoum (B677900) as the rodenticides.

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3-(4'-Bromo[1,1'-biphenyl]-4-yl)-1,2,3,4-tetrahydro-1-naphthalenol

Q: What is the CAS number for 3-(4'-Bromo[1,1'-biphenyl]-4-yl)-1,2,3,4-tetrahydro-1-naphthalenol?

The CAS number of 3-(4'-Bromo[1,1'-biphenyl]-4-yl)-1,2,3,4-tetrahydro-1-naphthalenol is 56181-82-9.

Cas number：56181-82-9
purity：99%

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Product Details

Factory Sells Best Quality 3-(4'-Bromo[1,1'-biphenyl]-4-yl)-1,2,3,4-tetrahydro-1-naphthalenol 56181-82-9 with GMP standards

Molecular Formula: C22H19BrO
Molecular Weight: 379.296
Appearance/Colour: Cream To Pale Solid Powder.
Boiling Point: 512.8 °C at 760 mmHg
PKA: 14.15±0.40(Predicted)
Flash Point: 263.9 °C
PSA： 20.23000
Density: 1.359 g/cm³
LogP: 5.87950

56181-82-9 Relevant articles

Synthesis and antitumor activity of 4-hydroxycoumarin derivatives

Jung, Jae-Chul,Lee, Ji-Ho,Oh, Seikwan,Lee, Jae-Gon,Park, Oee-Sook

, p. 5527 - 5531 (2007/10/03)

A series of 4-hydroxycoumarin derivative...

56181-82-9 Process route

: 60313-01-1
3-(4''-Bromobiphenyl-4'-yl)-1,2,3,4-tetrahydronaphthalen-1-one

: 56181-82-9
(+/-)-cis/trans-3-(4''-Bromobiphenyl-4'-yl)-1,2,3,4-tetrahydronaphthalen-1-ol

Conditions

Conditions	Yield
With sodium tetrahydroborate; In ethanol; at 20 ℃; for 2h;	85%

: 92-66-0
4-bromo-1,1'-biphenyl

: 56181-82-9
(+/-)-cis/trans-3-(4''-Bromobiphenyl-4'-yl)-1,2,3,4-tetrahydronaphthalen-1-ol

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: 88 percent / AlCl₃ / CH₂Cl₂ / 16 h / -10 °C 2: 95 percent / Zn; I₂ / benzene / 1 h / Heating 3: 85 percent / Et₃SiH; TFA; BF₃Et₂O / CH₂Cl₂ / 8 h / Heating 4: 93 percent / aq. KOH / 8 h / Heating 5: 80 percent / polyphosphoric acid / 1 h / 80 °C 6: 85 percent / NaBH₄ / ethanol / 2 h / 20 °C With* triethylsilane; potassium hydroxide; sodium tetrahydroborate; aluminium trichloride; PPA; boron trifluoride diethyl etherate; iodine; trifluoroacetic acid; zinc; In ethanol; dichloromethane; benzene; 1: Friedel-Crafts acylation / 2: Reformatsky reaction;

Yield

Multi-step reaction with 6 steps

1: 88 percent / AlCl₃ / CH₂Cl₂ / 16 h / -10 °C

2: 95 percent / Zn; I₂ / benzene / 1 h / Heating

3: 85 percent / Et₃SiH; TFA; BF₃*Et₂O / CH₂Cl₂ / 8 h / Heating

4: 93 percent / aq. KOH / 8 h / Heating

5: 80 percent / polyphosphoric acid / 1 h / 80 °C

6: 85 percent / NaBH₄ / ethanol / 2 h / 20 °C

With triethylsilane; potassium hydroxide; sodium tetrahydroborate; aluminium trichloride; PPA; boron trifluoride diethyl etherate; iodine; trifluoroacetic acid; zinc; In ethanol; dichloromethane; benzene; 1: Friedel-Crafts acylation / 2: Reformatsky reaction;

56181-82-9 Upstream products

60313-01-1
3-(4''-Bromobiphenyl-4'-yl)-1,2,3,4-tetrahydronaphthalen-1-one
92-66-0
4-bromo-1,1'-biphenyl
60312-95-0
1-[4'-bromo(1,1'-biphenyl)-4-yl]-2-phenylethan-1-one
103-80-0
phenylacetyl chloride

56181-82-9 Downstream products

56073-10-0
(3-[(1R,3S)-3-[4-(4-bromophenyl)phenyl]-1,2,3,4-tetrahydronaphthalen-1-yl]-4-hydroxychromen-2-one)
56073-10-0
(3-[(1R,3R)-3-[4-(4-bromophenyl)phenyl]-1,2,3,4-tetrahydronaphthalen-1-yl]-4-hydroxychromen-2-one)
70942-04-0
1-Bromo-3-(4'-bromo-biphenyl-4-yl)-1,2,3,4-tetrahydro-naphthalene