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1.What is the Atorvastatin ?
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![(3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid t-butyl ester](/upload/2026/10/0ea84d4d056943dda7b7eae1ed36f122_c2f80e92-50cb-4fa4-9014-3cb5a2e4caa3.png)
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134395-00-9
(3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid t-butyl ester
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134523-00-5,110862-48-1
atorvastatin
| Conditions | Yield |
|---|---|
|
With
sodium hydroxide;
In
tetrahydrofuran; water;
at 20 ℃;
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With
methanol; potassium hydroxide; water;
|
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(3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid t-butyl ester;
With
methanol; sodium hydroxide; water;
In
tert-butyl methyl ether;
for 2.08333 - 7.08333h;
Heating / reflux;
With
hydrogenchloride;
pH=8.0 - 8.2;
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|
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(3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid t-butyl ester;
With
sodium hydroxide; water;
In
2,2'-oxybis(2-methyl-propane);
at 30 ℃;
With
hydrogenchloride;
In
water;
at 75 - 85 ℃;
for 18h;
Product distribution / selectivity;
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With
sodium hydroxide; water;
at 75 - 80 ℃;
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|
|
With
methanol; sodium hydroxide; water;
at 80 ℃;
for 3h;
|
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|
With
sodium hydroxide; water;
In
butanone;
at 60 ℃;
for 2h;
|
|
|
With
sodium hydroxide; water;
at 75 - 80 ℃;
for 12h;
|
|
|
(3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid t-butyl ester;
With
sodium hydroxide;
In
tetrahydrofuran; water;
at 0 - 20 ℃;
for 6h;
With
hydrogenchloride;
In
tetrahydrofuran; dichloromethane; water;
at 20 ℃;
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54.8 g
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(3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid t-butyl ester;
With
sodium hydroxide;
In
tetrahydrofuran; water;
at 0 - 20 ℃;
for 6h;
Inert atmosphere;
With
hydrogenchloride;
In
tetrahydrofuran; dichloromethane; water;
enantioselective reaction;
Inert atmosphere;
|
35.5 mg
|
|
With
sodium hydroxide;
|
|
|
(3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid t-butyl ester;
With
sodium hydroxide;
In
methanol; tert-butyl methyl ether; water;
at 40 - 50 ℃;
pH=10.5-11.5;
With
sodium hydroxide;
In
methanol; tert-butyl methyl ether; water;
at 50 - 55 ℃;
pH=12-13;
|
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124401-38-3
4-methyl-3-oxo-N-phenylpentanamide
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134523-00-5,110862-48-1
atorvastatin
| Conditions | Yield |
|---|---|
|
Multi-step reaction
with
5
steps
1: β-alanine; glacial acetic acid / hexane / Heating
2: 3-ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide; triethylamine / ethanol / Heating
3: pivalic acid / tetrahydrofuran; toluene; heptane / Heating
4: HCl / tetrahydrofuran; H2
O / 20 °C
5: sodium hydroxide / H2
O; tetrahydrofuran / 20 °C
With
hydrogenchloride; sodium hydroxide; 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; acetic acid; triethylamine; 3-amino propanoic acid; Trimethylacetic acid;
In
tetrahydrofuran; ethanol; hexane; n-heptane; water; toluene;
1: Condensation / 2: Addition / 3: Cycloaddition / 4: Hydrolysis / 5: Hydrolysis;
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2.What is the CAS number for Atorvastatin ?
The CAS number of Atorvastatin is 110862-48-1.
More information of Atorvastatin 110862-48-1 are:
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CAS?Number |
110862-48-1 |
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Density |
1.236 g/cm3 |
|
Melting Point |
176-178℃ |
|
Boiling Point |
722.198 °C at 760 mmHg |
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Flash Point |
390.572 °C |
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HS CODE |
2942000000 |
|
PSA |
111.79000 |
|
LogP |
6.38660 |
|
Pka |
4.29±0.10(Predicted) |
3.What are another words for Atorvastatin ?
Synonyms?for?Atorvastatin 110862-48-1:1H-Pyrrole-1-heptanoicacid, 2-(4-fluorophenyl)-b,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-,(R*,R*)-;
4.What is the molecular formula of Atorvastatin?
The chemical formula of ?Atorvastatin is?C33 H35 FN2 O5 which containing 33 Carbon atoms,35 Hydrogen atoms,1 Fluorine atoms,2 Nitrogen atoms and 5 Oxygen atoms,and the molecular weight of??Atorvastatin?is 558.65.
5.What is Atorvastatin (110862-48-1) used for?
InChI:InChI=1/C33H34FNO5.Ca/c1-21(2)31-30(33(40)24-11-7-4-8-12-24)29(22-9-5-3-6-10-22)32(23-13-15-25(34)16-14-23)35(31)18-17-26(36)19-27(37)20-28(38)39;/h3-16,21,26-27,36-37H,17-20H2,1-2H3,(H,38,39);/q;+2/p-1/t26-,27-;/m1./s1
Relevant articles related to Atorvastatin:
|
Article |
Source |
|
Synthesis method of atorvastatin calcium |
- Paragraph 0051-0053, (2018/12/02) |
|
A decongestant atorvastatin |
- Paragraph 0094-0099, (2017/01/17) |
6.Buy Atorvastatin with the best price .
Shijiazhuang Saiya Chemical Co., Ltd is a quality supplier of Atorvastatin. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on Atorvastatin 110862-48-1.